Ua hoʻomohala ka poʻe ʻepekema i kahua no ka hui ʻana i nā mea waiwai nanosized, a i ʻole "nāno-objects," o nā ʻano ʻokoʻa loa -- inorganic a i ʻole organik -- i loko o nā hale 3-D i makemake ʻia.ʻOiai ua hoʻohana maikaʻi ʻia ʻo self-assembly (SA) no ka hoʻonohonoho ʻana i nā nanomaterials o nā ʻano like ʻole, ʻo ke kaʻina hana he ʻōnaehana kikoʻī loa, e hana ana i nā hale like ʻole e pili ana i nā waiwai intrinsic o nā mea.E like me ka mea i hōʻike ʻia i loko o kahi pepa i paʻi ʻia i kēia lā ma Nature Materials, hiki ke hoʻohana ʻia kā lākou DNA-programmable nanofabrication platform e hoʻonohonoho i nā ʻano mea like ʻole 3-D i nā ala like i kuhikuhi ʻia ma ka nanoscale (billionths o ka mika), kahi o ka optical optical, chemical. , a puka mai na waiwai e ae.
"ʻO kekahi o nā kumu nui ʻaʻole ʻo SA he ʻano koho no nā noi kūpono ʻo ia ʻaʻole hiki ke hoʻohana ʻia ke kaʻina SA like ma kahi ākea o nā mea e hana ai i nā papa kuhikuhi 3-D like ʻole mai nā nanokompone like ʻole," i wehewehe ʻia e ka mea kākau like ʻo Oleg Gang. , alakaʻi o ka Soft and Bio Nanomaterials Group ma ka Center for Functional Nanomaterials (CFN) -- he US Department of Energy (DOE) Office of Science User Facility ma Brookhaven National Laboratory -- a he polopeka o Chemical Engineering and Applied Physics and ʻEpekema Materials ma Columbia Engineering."Maʻaneʻi, ua hoʻokaʻawale mākou i ke kaʻina SA mai nā waiwai waiwai ma o ka hoʻolālā ʻana i nā papa DNA polyhedral paʻa i hiki ke hoʻopili i nā ʻano nano-mea like ʻole a i ʻole organik, me nā metala, semiconductor, a me nā protein a me nā enzymes."
Ua hana nā ʻepekema ʻepekema i nā kiʻi DNA synthetic i ke ʻano o ka cube, octahedron, a me tetrahedron.Aia i loko o nā papa he "lima" DNA i hiki i nā mea nano wale nō me ke kaʻina DNA hoʻohui.ʻO kēia mau mea voxels - ka hoʻohui ʻana o ke kiʻi DNA a me ka nano-object - ʻo ia nā poloka hale kahi e hiki ai ke hana ʻia nā hale macroscale 3-D.Hoʻopili nā papa i kekahi me ka nānā ʻole i ke ʻano o ka nano-mea i loko (a ʻaʻole paha) e like me nā kaʻina hoʻohui i hoʻopaʻa ʻia me ko lākou vertices.Ma muli o ko lākou ʻano, ʻokoʻa ka helu o nā vertice a no laila e hana ʻia nā hale ʻokoʻa.ʻO kēlā me kēia nano-mea i hoʻokipa ʻia i loko o nā kiʻi e lawe i kēlā ʻano hana kiʻi kikoʻī.
No ka hōʻike ʻana i kā lākou hui ʻana, ua koho nā ʻepekema i nā nanoparticles metallic (gula) a me semiconducting (cadmium selenide) a me kahi protein bacterial (streptavidin) ma ke ʻano he mea nano-anorganic a me ka organik e waiho ʻia i loko o nā pā DNA.ʻO ka mea mua, ua hōʻoia lākou i ka pono o nā papa DNA a me ka hoʻokumu ʻana i nā voxels waiwai ma ke kiʻi ʻana me nā microscopes electron ma ka CFN Electron Microscopy Facility a me ka Van Andel Institute, nona kahi hui o nā mea kani e hana ana i nā mahana cryogenic no nā laʻana olaola.A laila ua hoʻāʻo lākou i nā ʻāpana lattice 3-D ma ka Coherent Hard X-ray Scattering and Complex Materials Scattering beamlines o ka National Synchrotron Light Source II (NSLS-II) -- kekahi DOE Office of Science User Facility ma Brookhaven Lab.Ua hana ʻo Columbia Engineering Bykhovsky Professor of Chemical Engineering Sanat Kumar a me kāna pūʻulu i ka hoʻohālike hoʻohālikelike e hōʻike ana i ka hoʻokolohua ʻana i nā hale lattice i nānā ʻia (ma muli o nā kumu hoʻopuehu x-ray) ʻo ia nā mea paʻa thermodynamically i hiki i nā voxels waiwai ke hana.
"ʻO kēia mau mea voxels e ʻae iā mākou e hoʻomaka i ka hoʻohana ʻana i nā manaʻo i loaʻa mai nā ʻātoma (a me nā mole) a me nā kristal a lākou i hana ai, a lawe i kēia ʻike nui a me ka waihona i nā ʻōnaehana hoihoi ma ka nanoscale," wehewehe ʻo Kumar.
Ua hōʻike nā haumāna o Gang ma Columbia pehea e hiki ai ke hoʻohana ʻia ke kahua hui e hoʻokele i ka hui ʻana o ʻelua mau ʻano mea like ʻole me nā hana kemika a me ka optical.I kekahi hihia, ua hui pū lākou i ʻelua enzymes, e hana ana i nā arrays 3-D me kahi kiʻekiʻe packing density.ʻOiai ʻaʻole i hoʻololi ʻia nā enzymes, ua hōʻike lākou i kahi piʻi ʻehā o ka hana enzymatic.Hiki ke ho'ohana 'ia kēia mau "nanoreactors" no ka ho'oponopono 'ana i nā hopena cascade a hiki ke hana i nā mea hana kemika.No ka hōʻikeʻike mea optical, ua hui pū lākou i ʻelua kala like ʻole o nā kiko quantum -- nā nanocrystals liʻiliʻi i hoʻohana ʻia e hana i nā hōʻike kīwī me ka saturation kala kiʻekiʻe a me ka ʻōlinolino.Ua hōʻike ʻia nā kiʻi i kiʻi ʻia me kahi microscope fluorescence i ka lattice i hana ʻia e mālama i ka maʻemaʻe kala ma lalo o ka palena diffraction (lōʻihi nalu) o ka mālamalama;hiki i kēia waiwai ke ʻae i ka hoʻomaikaʻi ʻana i ka hoʻonā koʻikoʻi i nā ʻano ʻike like ʻole a me nā ʻenehana kamaʻilio optical.
"Pono mākou e noʻonoʻo hou pehea e hana ʻia ai nā mea hana a pehea lākou e hana ai," wahi a Gang."ʻAʻole pono paha ka hoʻolālā hou ʻana o nā mea; ʻo ka hoʻopili wale ʻana i nā mea i loaʻa i nā ala hou e hiki ke hoʻonui i ko lākou mau waiwai. Hiki paha i kā mākou paepae ke lilo i ʻenehana hiki ke 'ʻoi aku ma mua o ka hana paʻi 3-D' e hoʻomalu i nā mea i nā unahi liʻiliʻi a me nā ʻano mea like ʻole. ʻO ka hoʻohana ʻana i ke ala like e hana ai i nā lattices 3-D mai nā mea nano i makemake ʻia o nā papa mea like ʻole, ka hoʻohui ʻana i nā mea i manaʻo ʻia he kūpono ʻole, hiki ke hoʻololi i ka nanomanufacturing."
Nā mea i hāʻawi ʻia e DOE/Brookhaven National Laboratory.Nānā: Hiki ke hoʻoponopono ʻia ka ʻike no ke ʻano a me ka lōʻihi.
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Ka manawa hoʻouna: Jan-14-2020