Eminyakeni yamuva, ubuchwepheshe be-nano-drug ubuchwepheshe obusha obudumile kubuchwepheshe bokulungiselela izidakamizwa.Izidakamizwa ze-Nano ezifana ne-nanoparticles, ibhola noma i-nano capsule nanoparticles njengesistimu ye-carrier, kanye nokusebenza kahle kwezinhlayiya ngendlela ethile ndawonye ngemva komuthi, kungenziwa futhi ngokuqondile ekucutshungulweni kobuchwepheshe be-nanoparticles.
Uma kuqhathaniswa nezidakamizwa ezivamile, izidakamizwa ze-nano zinezinzuzo eziningi ezingenakuqhathaniswa nezidakamizwa ezivamile:
Umuthi wokukhululwa kancane, ushintsha isigamu sempilo yomuthi emzimbeni, ukwandisa isikhathi sokusebenza somuthi;
Isitho esithile esihlosiwe singafinyelelwa ngemva kokwenziwa isidakamizwa esiqondiswayo;
Ukunciphisa umthamo, ukunciphisa noma ukuqeda umphumela ohlangothini onobuthi ngaphansi kwesisekelo sokuqinisekisa ukusebenza kahle;
Indlela yokuthutha i-membrane iyashintshwa ukuze kwandiswe ukungeneka komuthi ku-biofilm, okuzuzisa ukumuncwa kwe-transdermal yesidakamizwa kanye nokudlala ukusebenza kahle kwezidakamizwa.
Ngakho-ke kulezo zidingo ngosizo lwenkampani yenethiwekhi ukuletha izidakamizwa ezindaweni ezihlosiwe, ukunikeza indima yokwelashwa ngokuya ngama-nanodrugs, idizayini yesiphathimandla sokuthuthukisa ukusebenza kahle kokukhomba izidakamizwa kubalulekile.
Muva nje umbiko wezindaba uthe inyuvesi yase-New South Wales, e-Australia, abacwaningi bathuthukise indlela entsha, bangashintsha ukuma kwe-nano drug carrier, lokhu kuzosiza ukuthuthwa kwezidakamizwa ezilwa nomdlavuza ezikhishwe ku-tumor, ukuthuthukisa umphumela we-anti -izidakamizwa zomdlavuza.
Ama-molecule e-polymer esixazululo angakhiwa ngokuzenzakalelayo isakhiwo se-vesicle esingenalutho esiyindilinga se-polymer, sinezinzuzo zokuzinza okuqinile, ukuhlukahluka okusebenzayo kusetshenziswa kabanzi njengomthwali wezidakamizwa, kodwa, ngokuphambene, njengamagciwane kanye negciwane emvelweni amashubhu, izinduku. , futhi izakhiwo zebhayoloji ezingezona eziyindilinga zingangena kalula emzimbeni.Ngenxa yokuthi ama-polymer vesicles anzima ukwenza ukwakheka okungeyona i-spherical, lokhu kukhawulela ikhono le-polymer ukuletha izidakamizwa lapho iphokophele khona emzimbeni womuntu ngezinga elithile.
Abacwaningi base-Australia basebenzisa i-cryoelectron microscopy ukuze babheke izinguquko zesakhiwo sama-molecule e-polymer esixazululweni.Bathola ukuthi ngokushintsha inani lamanzi ku-solvent, ukwakheka nobukhulu be-polymer vesicles kungalungiswa ngokushintsha inani lamanzi ku-solvent.
Umbhali oholayo kanye nenyuvesi yase-New South Wales Institute of chemistry of pine parr sol, uthe: "le mpumelelo isho ukuthi singakwazi ukukhiqiza i-polymer vesicle shape ingase ishintshe nemvelo, efana ne-oval noma i-tubular, kanye nephakheji yezidakamizwa kuyo."Ubufakazi bokuqala buphakamisa ukuthi abathwali bezidakamizwa be-nano-drug bemvelo, abangasindilinga bangase bangene kumaseli wesimila.
Ucwaningo lushicilelwe ku-inthanethi kumagazini wakamuva wejenali yezokuxhumana zemvelo.
Isikhathi sokuthumela: Mar-16-2018